SCHEMBL8913741

SCHEMBL8913741

CCCc1ccc(OC(=O)c2ccc(CCC[Si](C)(C)O[Si](C)(C)C)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.49
THRB P10828 5/20 0.49
SMN1; SMN2 Q16637 4/20 0.48
KMT2A Q03164 4/20 0.48
PLA2G1B P04054 1/20 0.48
ATG4B Q9Y4P1 1/20 0.48
NPC1 O15118 3/20 0.43
PRSS1 P07477 2/20 0.43
ACR P10323 1/20 0.43
CASP3 P42574 1/20 0.43
RAB9A P51151 1/20 0.43
SENP8 Q96LD8 1/20 0.43
SENP7 Q9BQF6 1/20 0.43
SENP6 Q9GZR1 1/20 0.43
LMNA P02545 2/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9304067 0.92 LMNA (0.54) MAPTTHRBSMN1; SMN2KMT2ANPC1
SCHEMBL8921077 0.92 MAPT (0.56) MAPTTHRBSMN1; SMN2KMT2APLA2G1B
SCHEMBL8913312 0.91 MAPT (0.51) MAPTTHRBSMN1; SMN2KMT2APLA2G1B
SCHEMBL9303224 0.90 MAPT (0.50) MAPTTHRBSMN1; SMN2KMT2ANPC1
SCHEMBL8913267 0.90 MAPT (0.50) MAPTTHRBSMN1; SMN2KMT2ANPC1
SCHEMBL8912855 0.86 LMNA (0.56) MAPTTHRBSMN1; SMN2KMT2ANPC1
SCHEMBL8914081 0.86 F2 (0.45) MAPTTHRBSMN1; SMN2PRSS1ACR
SCHEMBL8915996 0.85 LMNA (0.58) MAPTSMN1; SMN2KMT2ANPC1PRSS1
SCHEMBL30354554 0.82 THRB (0.62) MAPTTHRBSMN1; SMN2KMT2APLA2G1B
SCHEMBL10633416 0.82 THRB (0.62) MAPTTHRBSMN1; SMN2KMT2APLA2G1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE35462-E Silylated benzoic acid derivatives CONSORTIUM FUR ELEKOCHEMISCHE IND. GMBH (DE) 1997-02-25 US disclosed
US-5277838-A Silylated benzoic acid derivatives CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1994-01-11 US disclosed
US-5106530-A Liquid crystals Consortium Fur Elektrochemische Ind. (DE) 1992-04-21 US disclosed