SCHEMBL8913829

SCHEMBL8913829

CCCCc1nc(Cl)c(C=O)n1Cc1ccc2nc(-c3ccccc3C(=O)O)ccc2c1.[NaH]

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 5/20 0.61
AGTR2 P50052 5/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8916330 0.99 AGTR1 (0.62) AGTR1AGTR2
SCHEMBL8913822 0.91 AGTR1 (0.58) AGTR1AGTR2
SCHEMBL8719876 0.90 AGTR1 (0.57) AGTR1AGTR2
SCHEMBL8913280 0.87 AGTR1 (0.77) AGTR1AGTR2
SCHEMBL33 0.87 AGTR1 (0.75) AGTR1AGTR2
SCHEMBL8326042 0.86 AGTR1 (0.78) AGTR1AGTR2
SCHEMBL8735381 0.83 AGTR1 (0.68) AGTR1AGTR2
SCHEMBL9467439 0.83 AGTR1 (0.61) AGTR1AGTR2
SCHEMBL9096716 0.82 AGTR1 (0.56) AGTR1AGTR2
SCHEMBL8912755 0.81 GP6 (0.55) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5665881-A CARDIOVASCULAR DISORDERS, HYPOTENSIVE, ANGIOTENSIN II ANTAGONIST THE GREEN CROSS CORPORATION (JP) 1997-09-09 US disclosed
EP-0693478-A1 Quinoline compounds THE GREEN CROSS CORPORATION (JP) 1996-01-24 EP disclosed
US-5478832-A Angiotensin II antagonists; cardiovascular disorders THE GREEN CROSS CORPORATION (JP) 1995-12-26 US disclosed
EP-0569013-A1 Quinoline compounds as angiotensin II antagonists THE GREEN CROSS CORPORATION (JP) 1993-11-10 EP disclosed