Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.59 |
| ▸ | MMP9 | P14780 | 6/20 | 0.59 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.59 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.54 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.54 |
| ▸ | MMP7 | P09237 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913854 | 0.93 | MMP2 (0.57) | MMP2MMP9ADAMTS4ITGB3ITGA2B | |
| SCHEMBL8913765 | 0.82 | F2 (0.49) | MMP2MMP9ADAMTS4ITGB3ITGA2B | |
| SCHEMBL697591 | 0.82 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL697592 | 0.82 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL4188026 | 0.82 | MMP2 (0.85) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 | |
| SCHEMBL8915384 | 0.81 | ADAMTS4 (0.54) | MMP2MMP9ADAMTS4ITGB3ITGA2B | |
| SCHEMBL8915081 | 0.81 | MMP2 (0.56) | MMP2MMP9ADAMTS4ITGB3ITGA2B | |
| SCHEMBL8914454 | 0.80 | P2RX7 (0.51) | ITGB3ITGA2BF2F10PLG | |
| SCHEMBL8915067 | 0.80 | MMP2 (0.56) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL6416586 | 0.75 | MMP2 (0.70) | MMP2MMP9ADAMTS4ADAMTS5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |