Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 4/20 | 0.38 |
| ▸ | RXRA | P19793 | 3/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008412 | 0.86 | RXRA (0.44) | HNF4ARXRA | |
| SCHEMBL8899696 | 0.82 | HNF4A (0.40) | HNF4ARXRAKDM1AHTR2CHTR2B | |
| SCHEMBL8888371 | 0.82 | RXRA (0.42) | HNF4ARXRAMAPTGAA | |
| SCHEMBL8008022 | 0.80 | RXRA (0.39) | HNF4ARXRA | |
| SCHEMBL8890308 | 0.73 | CCNB2 (0.40) | HNF4ARXRACCNB2CDK1CDK4 | |
| SCHEMBL6916083 | 0.73 | CCNB2 (0.40) | HNF4ARXRACCNB2CDK1CDK4 | |
| SCHEMBL6917161 | 0.73 | MAOB (0.55) | HNF4ARXRABRD4MAPTTDP1 | |
| SCHEMBL6917354 | 0.71 | CCNB2 (0.38) | HNF4ARXRACCNB2CDK1CDK4 | |
| SCHEMBL28061354 | 0.71 | GLRA1 (0.47) | HTR2CHTR1A | |
| SCHEMBL6473706 | 0.71 | LIPE (0.56) | HNF4ARXRAHIF1AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012853-A1 | DIMER-SELECTIVE RXR MODULATORS AND METHODS FOR THEIR USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-04-10 | — | — | WO | disclosed |