Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.37 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915164 | 0.82 | HNF4A (0.38) | HNF4ARXRAMAPTMAPK1TDP1 | |
| SCHEMBL6917161 | 0.76 | MAOB (0.55) | HNF4ARXRAMAPTTDP1L3MBTL1 | |
| SCHEMBL6473706 | 0.74 | LIPE (0.56) | HNF4ARXRALIPEMAPTMAPK1 | |
| SCHEMBL6477273 | 0.73 | HTR2A (0.47) | HNF4ARXRALIPEMAPTMAPK1 | |
| SCHEMBL6918873 | 0.73 | RXRA (0.45) | HNF4ARXRACYP26A1CYP26B1LIPE | |
| SCHEMBL6916114 | 0.72 | LIPE (0.40) | HNF4ARXRALIPEMAPTMAPK1 | |
| SCHEMBL6915309 | 0.71 | RXRA (0.43) | HNF4ARXRACYP26A1CYP26B1LIPE | |
| SCHEMBL31528235 | 0.70 | KDM4E (0.41) | LIPECYP3A4HTR2CKDM1ARAB9A | |
| SCHEMBL6033110 | 0.70 | L3MBTL1 (0.41) | HNF4ARXRALIPEMAPTMAPK1 | |
| SCHEMBL8525570 | 0.69 | RARG (0.53) | RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012853-A1 | DIMER-SELECTIVE RXR MODULATORS AND METHODS FOR THEIR USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-04-10 | — | — | WO | disclosed |