Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8914321 | 0.91 | ALDH1A1 (0.50) | LMNAALDH1A1HTTKDM4EHSD17B10 | |
| SCHEMBL893543 | 0.85 | ALDH1A1 (0.66) | LMNAALDH1A1HTTKDM4EHSD17B10 | |
| SCHEMBL893545 | 0.85 | ALDH1A1 (0.66) | LMNAALDH1A1HTTKDM4EHSD17B10 | |
| SCHEMBL15648472 | 0.81 | ALDH1A1 (0.72) | LMNAALDH1A1HTTTRPA1TSHR | |
| SCHEMBL6962263 | 0.81 | ALDH1A1 (0.72) | LMNAALDH1A1HTTTRPA1TSHR | |
| SCHEMBL3721226 | 0.80 | LMNA (0.63) | LMNAALDH1A1HTTTRPA1TSHR | |
| SCHEMBL28864063 | 0.80 | LMNA (0.63) | LMNAALDH1A1HTTTRPA1TSHR | |
| SCHEMBL27583610 | 0.79 | MMP1 (0.54) | LMNAALDH1A1HTTKDM4EHSD17B10 | |
| SCHEMBL8916308 | 0.79 | LMNA (0.66) | LMNAALDH1A1HTTTRPA1TSHR | |
| SCHEMBL16635434 | 0.79 | ALDH1A1 (0.59) | LMNAALDH1A1HTTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |