Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15648472 | 1.00 | ALDH1A1 (0.72) | ALDH1A1HTTMAPTTDP1LMNA | |
| SCHEMBL893543 | 0.95 | ALDH1A1 (0.66) | ALDH1A1HTTMAPTTDP1LMNA | |
| SCHEMBL893545 | 0.95 | ALDH1A1 (0.66) | ALDH1A1HTTMAPTTDP1LMNA | |
| SCHEMBL16635434 | 0.91 | ALDH1A1 (0.59) | ALDH1A1HTTMAPTTDP1LMNA | |
| SCHEMBL15832928 | 0.91 | ALDH1A1 (0.59) | ALDH1A1HTTMAPTTDP1LMNA | |
| SCHEMBL6954687 | 0.88 | MAPT (0.59) | ALDH1A1HTTMAPTTDP1LMNA | |
| SCHEMBL8150933 | 0.88 | MAPT (0.59) | ALDH1A1HTTMAPTTDP1LMNA | |
| SCHEMBL2977278 | 0.88 | ALDH1A1 (0.72) | ALDH1A1HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL1385016 | 0.88 | ALDH1A1 (0.72) | ALDH1A1HTTMAPTLMNASMN1; SMN2 | |
| SCHEMBL3717708 | 0.87 | ALDH1A1 (0.71) | ALDH1A1HTTMAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9388166-B2 | 6-aminoindole derivatives as TRP channel antagonists | HOFFMAN-LA ROCHE INC. (US) | 2016-07-12 | — | — | US | disclosed |
| US-20150284375-A1 | HETEROCYCLIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME | AJINOMOTO CO., INC. (JP) | 2015-10-08 | — | — | US | disclosed |
| EP-2909172-A1 | 6-AMINOINDOLE DERIVATIVES AS TRP CHANNEL ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2015-08-26 | — | — | EP | disclosed |
| US-20150218133-A1 | 6-AMINOINDOLE DERIVATIVES AS TRP CHANNEL ANTAGONISTS | HOFFMANN-LA ROCHE INC. (US) | 2015-08-06 | — | — | US | disclosed |
| WO-2014098098-A1 | HETEROCYCLIC AMIDE DERIVATIVE, AND MEDICINE CONTAINING SAME | 味の素株式会社 (JP) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014060328-A1 | 6-AMINOINDOLE DERIVATIVES AS TRP CHANNEL ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-24 | — | — | WO | disclosed |
| EP-1060178-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER (US) | 2003-09-03 | — | — | EP | disclosed |
| US-6610707-B1 | Moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage. | PFIZER INC. | 2003-08-26 | — | — | US | disclosed |
| EP-1060178-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999045006-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF ROTAMASE ENZYMES | PFIZER INC. (US) | 1999-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284375-A1 | HETEROCYCLIC AMIDE DERIVATIVE AND MEDICINE CONTAINING SAME | TRPA1, TRPV1, TRPV2 | ALDH1A1 619/4885HTT 617/4885MAPT 1391/4885 |
| US-20150218133-A1 | 6-AMINOINDOLE DERIVATIVES AS TRP CHANNEL ANTAGONISTS | TRPC6, TRPC5, HTR6 | ALDH1A1 952/4885HTT 765/4885MAPT 1173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.