Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916323 | 1.00 | DCAF1 (0.42) | DCAF1SMN1; SMN2KDM4ERECQLGAA | |
| SCHEMBL8916027 | 0.85 | DCAF1 (0.35) | DCAF1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL8916020 | 0.85 | DCAF1 (0.35) | DCAF1SMN1; SMN2KMT2AMEN1MAPK1 | |
| SCHEMBL8914261 | 0.82 | MAPT (0.35) | SMN1; SMN2KDM4ERECQLGAAPKM | |
| SCHEMBL8914267 | 0.82 | MAPT (0.35) | SMN1; SMN2KDM4ERECQLGAAPKM | |
| SCHEMBL8912643 | 0.80 | MAPK1 (0.43) | DCAF1KDM4EALDH1A1MAPK1MAPT | |
| SCHEMBL8912655 | 0.80 | MAPK1 (0.43) | DCAF1KDM4EALDH1A1MAPK1MAPT | |
| SCHEMBL8915198 | 0.70 | ALDH1A1 (0.55) | SMN1; SMN2KDM4EGAAATMKMT2A | |
| SCHEMBL8912941 | 0.68 | RAB9A (0.34) | SMN1; SMN2KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL8912946 | 0.68 | RAB9A (0.34) | SMN1; SMN2KDM4EKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5606073-A | INTERMEDIATES FOR ADENOSINE ANTAGONISTS | EISAI CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5541213-A | ADENOSINE A1 RECEPTOR ANTAGONISTS, TREATMENT OF KIDNEY DISORDERS | EISAI CO., LTD. (JP) | 1996-07-30 | — | — | US | disclosed |
| EP-0630894-A1 | Propenoic acid derivatives as adenosine A1 antagonists | Eisai Co., Ltd. (JP) | 1994-12-28 | — | — | EP | disclosed |