Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.43 |
| ▸ | F11 | P03951 | 4/20 | 0.39 |
| ▸ | DCAF1 | Q9Y4B6 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.38 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8912655 | 1.00 | MAPK1 (0.43) | MAPK1F11DCAF1GSK3BMAPK3 | |
| SCHEMBL8914891 | 0.82 | F11 (0.39) | F11GSK3BNPC1MAPTRAB9A | |
| SCHEMBL8914900 | 0.82 | F11 (0.39) | F11GSK3BNPC1MAPTRAB9A | |
| SCHEMBL8912946 | 0.81 | RAB9A (0.34) | MAPK1F11NPC1MAPTRAB9A | |
| SCHEMBL8912941 | 0.81 | RAB9A (0.34) | MAPK1F11NPC1MAPTRAB9A | |
| SCHEMBL8916323 | 0.80 | DCAF1 (0.42) | MAPK1F11DCAF1MAPTKDM4E | |
| SCHEMBL8916315 | 0.80 | DCAF1 (0.42) | MAPK1F11DCAF1MAPTKDM4E | |
| SCHEMBL8916027 | 0.77 | DCAF1 (0.35) | MAPK1F11DCAF1GSK3BNPC1 | |
| SCHEMBL8916020 | 0.77 | DCAF1 (0.35) | MAPK1F11DCAF1GSK3BNPC1 | |
| SCHEMBL8912912 | 0.67 | ALDH1A1 (0.42) | F11MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5606073-A | INTERMEDIATES FOR ADENOSINE ANTAGONISTS | EISAI CO., LTD. (JP) | 1997-02-25 | — | — | US | disclosed |
| US-5541213-A | ADENOSINE A1 RECEPTOR ANTAGONISTS, TREATMENT OF KIDNEY DISORDERS | EISAI CO., LTD. (JP) | 1996-07-30 | — | — | US | disclosed |
| EP-0630894-A1 | Propenoic acid derivatives as adenosine A1 antagonists | Eisai Co., Ltd. (JP) | 1994-12-28 | — | — | EP | disclosed |