SCHEMBL8917175

SCHEMBL8917175

CC(=O)c1nccnc1NC(C)c1c(Cl)cccc1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 1/20 0.38
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37
MAPK1 P28482 2/20 0.35
MAPK3 P27361 1/20 0.35
L3MBTL1 Q9Y468 2/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
KDM4E B2RXH2 1/20 0.34
ASPH Q12797 1/20 0.34
KDM8 Q8N371 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
KMT2A Q03164 1/20 0.34
TYK2 P29597 2/20 0.33
TOP1 P11387 1/20 0.33
BDKRB1 P46663 1/20 0.33
SCD O00767 1/20 0.33
MT-CO2 P00403 1/20 0.33
JAK2 O60674 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8917760 0.83 DHODH (0.36) DHODHALDH1A1GAARAB9ASMN1; SMN2
SCHEMBL8916607 0.82 DHODH (0.45) DHODHALDH1A1GAAL3MBTL1RAB9A
SCHEMBL8918547 0.70 MEN1 (0.44) ALDH1A1MAPK1L3MBTL1RAB9ASMN1; SMN2
SCHEMBL8790511 0.70 CYP1A2 (0.42) ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A
SCHEMBL8918710 0.69 HPGD (0.64) ALDH1A1GAAL3MBTL1RAB9ASMN1; SMN2
SCHEMBL365395 0.68 ALDH1A1 (0.45) DHODHALDH1A1GAAL3MBTL1RAB9A
SCHEMBL2402396 0.66 CYP1A2 (0.39) ALDH1A1MAPK1MAPK3
SCHEMBL22261234 0.65 JAK1 (0.46) TYK2JAK2JAK1
SCHEMBL277948 0.65 PDE3B (0.45) ALDH1A1GAAL3MBTL1RAB9ASMN1; SMN2
SCHEMBL19205602 0.63 CYP2C19 (0.46) ALDH1A1GAARAB9ASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP claimed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO claimed
US-5604230-A USEFUL IN INHIBITING THE REPLICATION OF HIV JANSSEN PHARMACEUTICA N.V. (BE) 1997-02-18 US disclosed
US-5587387-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-12-24 US disclosed
US-5552430-A ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1996-09-03 US disclosed
US-5550135-A ANTIRETROVIRAL AGENTS; TREATING HUMAN IMMUNODEFICIENCY VIRUS INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-08-27 US disclosed
US-5541215-A ANTIRETROVIRAL COMPOUNDS; TREATING HIV INFECTIONS JANSSEN PHARMACEUTICA N.V. (BE) 1996-07-30 US disclosed
US-5480997-A VIRICIDE FOR HIV JANSSEN PHARMACEUTICA N.V. (BE) 1996-01-02 US disclosed
EP-0620811-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1994-10-26 EP disclosed
WO-1993013069-A1 HETEROCYCLE-SUBSTITUTED BENZYLAMINE DERIVATIVES AS ANTIRETROVIRAL COMPOUNDS JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-08 WO disclosed