Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.68 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9793444 | 0.94 | OPRM1 (0.77) | OPRM1OPRK1OPRL1SIGMAR1BCHE | |
| SCHEMBL7943390 | 0.85 | OPRM1 (0.66) | OPRM1OPRK1OPRL1CYP2D6SLC6A4 | |
| SCHEMBL8133153 | 0.82 | BCHE (0.63) | OPRM1OPRK1OPRL1SIGMAR1BCHE | |
| SCHEMBL8446454 | 0.81 | OPRM1 (0.62) | OPRM1OPRK1OPRL1HTR1DHTR1B | |
| SCHEMBL14280723 | 0.81 | OPRM1 (1.00) | OPRM1OPRK1OPRL1ACHESLC6A4 | |
| SCHEMBL7532398 | 0.80 | OPRM1 (0.77) | OPRM1OPRK1OPRL1SIGMAR1CYP2D6 | |
| SCHEMBL9032088 | 0.79 | OPRM1 (0.75) | OPRM1OPRK1OPRL1CYP2D6SLC6A4 | |
| SCHEMBL2721792 | 0.78 | BCHE (0.51) | SIGMAR1BCHEACHEKDM4EATM | |
| SCHEMBL2926854 | 0.78 | KDM4E (0.67) | CYP2D6SLC6A4KDM4EATMHTR1D | |
| SCHEMBL9173444 | 0.77 | SIGMAR1 (0.57) | OPRM1OPRK1OPRL1SIGMAR1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607960-A | Indole derivatives as 5-HT1-like agonists for use in migraine | PFIZER INC. (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| EP-0695301-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |