Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 4/20 | 0.63 |
| ▸ | ACHE | P22303 | 4/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.63 |
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127891 | 0.88 | OPRM1 (0.64) | BCHEACHESIGMAR1HTR1ASLC6A4 | |
| SCHEMBL8124362 | 0.87 | SLC6A4 (0.56) | HTR1ASLC6A4 | |
| SCHEMBL8120129 | 0.87 | HTR1A (0.56) | BCHEACHESIGMAR1HTR1AOPRM1 | |
| SCHEMBL8130150 | 0.86 | HTR1D (0.49) | BCHEACHESIGMAR1HTR1AOPRM1 | |
| SCHEMBL8131987 | 0.84 | SIGMAR1 (0.65) | BCHEACHESIGMAR1HTR1ASLC6A4 | |
| SCHEMBL6214011 | 0.84 | SLC6A4 (0.61) | ACHEHTR1ASLC6A4 | |
| SCHEMBL8129624 | 0.82 | GAA (0.55) | BCHEACHESIGMAR1HTR1ASLC6A4 | |
| SCHEMBL8917214 | 0.82 | OPRM1 (0.68) | BCHEACHESIGMAR1SLC6A4OPRM1 | |
| SCHEMBL8126815 | 0.80 | HTR6 (0.52) | BCHEACHEHTR1AHTR1DHTR1B | |
| SCHEMBL8133273 | 0.80 | SLC6A4 (0.64) | HTR1ASLC6A4HTR1DHTR1BGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610134-B1 | Indole derivatives as 5-HT1-like agonists | ADIR (FR) | 2000-04-05 | — | — | EP | disclosed |
| US-5348968-A | Migraines | ADIR ET COMPAGNIE (FR) | 1994-09-20 | — | — | US | disclosed |
| EP-0610134-A1 | Indole, indazole and benzisoxazole derivatives as 5-HT1-like agonists | ADIR ET COMPAGNIE (FR) | 1994-08-10 | — | — | EP | disclosed |