Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8916643 | 0.89 | PNMT (0.34) | PNMTTAAR1TBXA2R | |
| Hydrochloric Acid SCHEMBL5363324 | 0.86 | PNMT (0.42) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL5348072 | 0.84 | PNMT (0.68) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL5358974 | 0.83 | PNMT (0.42) | PNMTDRD2DRD4DRD3PGR | |
| Hydrochloric Acid SCHEMBL5366069 | 0.83 | PNMT (0.42) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL9245137 | 0.81 | PNMT (0.68) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL5357566 | 0.81 | PNMT (0.68) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL5357887 | 0.81 | PNMT (0.68) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL5366733 | 0.81 | PNMT (0.72) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL8917797 | 0.80 | PNMT (0.49) | PNMTDRD2DRD4DRD3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668230-A | METALLOCENE WITH ETHYLENE BRIDGED FLUORENE UNITS, ALUMOXANE COCATALYST | PHILLIPS PETROLEUM COMPANY (US) | 1997-09-16 | — | — | US | claimed |