Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8919223 | 0.91 | THRA (0.37) | DAOALDH1A1KDM4ELMNAHTT | |
| SCHEMBL8921146 | 0.84 | DAO (0.41) | DAOALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL8922856 | 0.81 | EIF4A3 (0.40) | DAOALDH1A1KDM4ELMNAGSK3B | |
| SCHEMBL8919183 | 0.80 | CHEK1 (0.43) | DAOALDH1A1KDM4ELMNAGSK3B | |
| SCHEMBL8919040 | 0.74 | PPARG (0.38) | DAOALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL7264698 | 0.73 | DAO (0.41) | DAOALDH1A1KDM4ECA12CA9 | |
| SCHEMBL7348389 | 0.73 | ALDH1A1 (0.54) | ALDH1A1KDM4EGSK3BHIF1ATRPA1 | |
| SCHEMBL12301234 | 0.69 | GRM1 (0.56) | ALDH1A1KDM4EHSD17B10THRBTP53 | |
| SCHEMBL9293801 | 0.67 | CA12 (0.53) | ALDH1A1KDM4ELMNAHTTGSK3B | |
| SCHEMBL8919065 | 0.66 | CA12 (0.56) | DAOALDH1A1KDM4ELMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |