Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Indoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indoline SCHEMBL28301724 | 0.90 | ALDH1A1 (0.45) | ALDH1A1CYP1A2NOTUMMAPK1DRD2 | |
| Indoline SCHEMBL9093000 | 0.88 | NOTUM (0.45) | ALDH1A1CYP1A2NOTUMMAPK1MAPT | |
| Indoline SCHEMBL5069264 | 0.85 | PARP10 (0.44) | ALDH1A1CYP1A2MAPK1DRD2DRD4 | |
| Indoline SCHEMBL17652456 | 0.85 | DRD2 (0.44) | ALDH1A1CYP1A2NOTUMMAPK1DRD2 | |
| Phenylacetic Acid SCHEMBL27898390 | 0.85 | AKR1B1 (0.55) | ALDH1A1CYP1A2DRD2DRD4PARP11 | |
| Succinic Acid Monobenzyl Ester SCHEMBL8919869 | 0.85 | NOTUM (0.50) | ALDH1A1CYP1A2NOTUMMAPK1MAPT | |
| Indoline SCHEMBL3905169 | 0.84 | HTR2C (0.50) | ALDH1A1DRD2DRD4PDPK1PARP1 | |
| Indoline SCHEMBL5120533 | 0.83 | DRD2 (0.46) | MAPK1DRD2DRD4PDPK1PARP1 | |
| Indoline SCHEMBL5629 | 0.82 | — | — | |
| Indoline SCHEMBL29360339 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691272-A | Carboxylate and heat-sensitive recording material using same | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5559247-A | Carboxylate and heat-sensitive recording material using same | MITSUI TOATSU CHEMICALS, INC. (JP) | 1996-09-24 | — | — | US | disclosed |