Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 10/20 | 0.64 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8918296 | 0.82 | MCHR1 (0.62) | MCHR1DRD2DRD3HTR1AADRA1A | |
| SCHEMBL8915757 | 0.79 | CTSS (0.51) | MCHR1CTSSDRD2DRD3DRD4 | |
| SCHEMBL8917783 | 0.78 | CTSS (0.50) | MCHR1CTSSDRD2SLC6A4MEN1 | |
| SCHEMBL8916428 | 0.78 | CTSS (0.49) | MCHR1CTSSDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL6897558 | 0.77 | DRD2 (0.58) | DRD2DRD3DRD4HTR1AADRA1A | |
| Hydrochloric Acid SCHEMBL8991890 | 0.77 | MCHR1 (0.56) | MCHR1DRD2DRD3HTR1AADRA1A | |
| SCHEMBL8916709 | 0.77 | CTSS (0.49) | MCHR1CTSSDRD2SLC6A4MEN1 | |
| Hydrochloric Acid SCHEMBL8920486 | 0.76 | CTSS (0.48) | MCHR1CTSSDRD2SLC6A4MEN1 | |
| Hydrochloric Acid SCHEMBL8917151 | 0.76 | MCHR1 (0.54) | MCHR1DRD2DRD3HTR1AADRA1A | |
| SCHEMBL8917663 | 0.76 | MCHR1 (0.62) | MCHR1DRD2DRD3HTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691330-A | ANTIPSYCHOTIC AGENT | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1997-11-25 | — | — | US | disclosed |
| US-5532240-A | ANTIPSYCHOTIC AGENTS AND ANTISEROTONIN AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1996-07-02 | — | — | US | disclosed |
| EP-0596125-A1 | CONDENSED THIOPHENE COMPOUND AND PHARMACEUTICAL USE THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1994-05-11 | — | — | EP | disclosed |