Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843536 | 0.81 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL8918758 | 0.80 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL7843538 | 0.79 | PTGS2 (0.48) | PTGS2PTGS1CDK5CDK5R1 | |
| SCHEMBL7839858 | 0.79 | PTGS2 (0.54) | PTGS2PTGS1 | |
| SCHEMBL7841796 | 0.79 | PTGS2 (0.54) | PTGS2PTGS1MAPK14 | |
| SCHEMBL7832074 | 0.78 | PTGS2 (0.60) | PTGS2MAPK14KDM4EMEN1KMT2A | |
| SCHEMBL7839802 | 0.77 | PTGS2 (0.57) | PTGS2PTGS1MAPK14MEN1KMT2A | |
| SCHEMBL7847056 | 0.76 | PTGDR2 (0.48) | PTGS2PTGS1MAPK14LMNA | |
| SCHEMBL7833920 | 0.76 | PTGS2 (0.58) | PTGS2PTGS1MAPK14ALDH1A1HPGD | |
| SCHEMBL7843106 | 0.75 | PTGS2 (0.57) | PTGS2PTGS1MAPK14KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |