Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053841 | 0.88 | DDB1 (0.65) | CRBNDDB1NPC1MAPK13MAPK12 | |
| SCHEMBL4871374 | 0.85 | KMT2A (0.46) | CRBNDDB1LMNAKMT2ANPC1 | |
| SCHEMBL8922504 | 0.85 | DDB1 (0.50) | CRBNDDB1TP53NPC1MAPK13 | |
| SCHEMBL8920781 | 0.85 | CRBN (0.52) | CRBNDDB1KMT2ANPC1MAPK13 | |
| SCHEMBL8921094 | 0.82 | LMNA (0.52) | CRBNDDB1LMNANPC1MAPK13 | |
| SCHEMBL8922817 | 0.79 | SLC6A2 (0.51) | CRBNDDB1TP53MAPK1LMNA | |
| SCHEMBL8924450 | 0.77 | MAPT (0.42) | TP53GAAMAPK1 | |
| SCHEMBL8920256 | 0.76 | LMNA (0.54) | CRBNDDB1TP53GAALMNA | |
| SCHEMBL8102823 | 0.76 | DDB1 (0.48) | CRBNDDB1TP53GAANPC1 | |
| SCHEMBL2489537 | 0.74 | CYP19A1 (0.47) | PRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |