Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 4/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117192 | 0.87 | MAPT (0.60) | DDB1CRBNMAPTTSHRALOX15 | |
| SCHEMBL8922504 | 0.82 | DDB1 (0.50) | DDB1CRBNMAPTTSHRALOX15 | |
| SCHEMBL8922817 | 0.81 | SLC6A2 (0.51) | DDB1CRBNMAPTTSHRALOX15 | |
| SCHEMBL8921094 | 0.81 | LMNA (0.52) | DDB1CRBNMAPTALDH1A1NPC1 | |
| SCHEMBL3053841 | 0.81 | DDB1 (0.65) | DDB1CRBNMAPTTSHRALDH1A1 | |
| SCHEMBL8920256 | 0.79 | LMNA (0.54) | DDB1CRBNMAPTTSHRALOX15 | |
| SCHEMBL8920289 | 0.76 | CRBN (0.50) | DDB1CRBNTP53ALDH1A1GAA | |
| SCHEMBL8920781 | 0.76 | CRBN (0.52) | DDB1CRBNALDH1A1NPC1MAPK13 | |
| SCHEMBL16212102 | 0.74 | TP53 (0.47) | TSHRTP53RECQLALDH1A1GAA | |
| SCHEMBL10930085 | 0.74 | LMNA (0.51) | DDB1CRBNMAPTTSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |