Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MLNR | O43193 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922504 | 0.85 | DDB1 (0.50) | NPC1CYP1A2CYP2C19TP53MAPT | |
| SCHEMBL8920256 | 0.84 | LMNA (0.54) | SLC6A3CYP1A2CYP2C19TP53MAPT | |
| SCHEMBL8102823 | 0.81 | DDB1 (0.48) | NPC1CYP1A2CYP2C19TP53MAPT | |
| SCHEMBL3053841 | 0.81 | DDB1 (0.65) | NPC1MAPTTSHRSMN1; SMN2DDB1 | |
| SCHEMBL8924355 | 0.79 | SLC6A2 (0.47) | SLC6A2SLC6A3SLC6A4MEN1KMT2A | |
| SCHEMBL8920781 | 0.79 | CRBN (0.52) | MEN1KMT2ANPC1SMN1; SMN2DDB1 | |
| SCHEMBL8920289 | 0.79 | CRBN (0.50) | KMT2ANPC1TP53MAPK1LMNA | |
| SCHEMBL7736643 | 0.76 | SLC6A2 (0.55) | SLC6A2SLC6A3SLC6A4MEN1KMT2A | |
| SCHEMBL260276 | 0.76 | SLC6A2 (0.55) | SLC6A2SLC6A3SLC6A4MEN1KMT2A | |
| SCHEMBL6261864 | 0.76 | SLC6A2 (0.55) | SLC6A2SLC6A3SLC6A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |