Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.49 |
| ▸ | STK4 | Q13043 | 2/20 | 0.49 |
| ▸ | STK3 | Q13188 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 3/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922043 | 0.97 | ALDH1A1 (0.67) | ALDH1A1HSD17B10HPGDALOX15LRRK2 | |
| SCHEMBL8923242 | 0.88 | ALDH1A1 (0.57) | ALDH1A1HSD17B10HPGDALOX15LRRK2 | |
| SCHEMBL8921644 | 0.88 | ALDH1A1 (0.57) | ALDH1A1HSD17B10HPGDALOX15KDM4E | |
| SCHEMBL8923375 | 0.88 | ALDH1A1 (0.63) | ALDH1A1HSD17B10HPGDALOX15LRRK2 | |
| SCHEMBL8922167 | 0.88 | HSD17B10 (0.57) | ALDH1A1HSD17B10HPGDALOX15LRRK2 | |
| SCHEMBL8921531 | 0.87 | ALDH1A1 (0.54) | ALDH1A1HSD17B10HPGDALOX15LRRK2 | |
| SCHEMBL27395864 | 0.87 | ALDH1A1 (0.79) | ALDH1A1HSD17B10HPGDALOX15LRRK2 | |
| SCHEMBL8923429 | 0.86 | HSD17B10 (0.55) | ALDH1A1HSD17B10HPGDALOX15LRRK2 | |
| SCHEMBL8921416 | 0.85 | ALDH1A1 (0.59) | ALDH1A1HSD17B10HPGDALOX15KDM4E | |
| SCHEMBL8921302 | 0.84 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HPGDALOX15LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | claimed |
| US-5414082-A | Anticonvulsants | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1995-05-09 | — | — | US | claimed |
| EP-0431371-A1 | 3-Aminopyrroles, process for this preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-06-12 | — | — | EP | claimed |
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | disclosed |
| US-5414082-A | Anticonvulsants | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1995-05-09 | — | — | US | disclosed |