Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | STK4 | Q13043 | 3/20 | 0.38 |
| ▸ | STK3 | Q13188 | 3/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922043 | 0.88 | ALDH1A1 (0.67) | HSD17B10ALDH1A1HPGDALOX15PRKDC | |
| SCHEMBL8920563 | 0.88 | ALDH1A1 (0.70) | HSD17B10ALDH1A1HPGDALOX15PRKDC | |
| SCHEMBL8923375 | 0.87 | ALDH1A1 (0.63) | HSD17B10ALDH1A1HPGDALOX15AKR1C3 | |
| SCHEMBL8923242 | 0.87 | ALDH1A1 (0.57) | HSD17B10ALDH1A1HPGDALOX15AKR1C3 | |
| SCHEMBL8921644 | 0.87 | ALDH1A1 (0.57) | HSD17B10ALDH1A1HPGDALOX15AKR1C3 | |
| SCHEMBL5675180 | 0.86 | ALDH1A1 (0.62) | HSD17B10ALDH1A1HPGDALOX15AKR1C3 | |
| SCHEMBL8923429 | 0.85 | HSD17B10 (0.55) | HSD17B10ALDH1A1HPGDALOX15TSHR | |
| SCHEMBL8921416 | 0.84 | ALDH1A1 (0.59) | HSD17B10ALDH1A1HPGDALOX15AKR1C3 | |
| SCHEMBL9133599 | 0.83 | ALDH1A1 (0.80) | HSD17B10ALDH1A1HPGDALOX15TSHR | |
| SCHEMBL9858266 | 0.81 | ALDH1A1 (0.48) | HSD17B10ALDH1A1HPGDALOX15AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | claimed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | claimed |
| EP-0431371-A1 | 3-Aminopyrroles, process for this preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-06-12 | — | — | EP | claimed |
| US-5684160-A | 3-aminopyrroles, methods for their synthesis and for their pharmaceutical use | ARZNEIMETTELWERK DRESDEN GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5502051-A | CENTRAL NERVOUS SYSTEM, ANTISPASMODIC | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 1996-03-26 | — | — | US | disclosed |