Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27630962 | 0.86 | CYP19A1 (0.55) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL8240311 | 0.85 | MAPT (0.65) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL22589459 | 0.84 | MAPT (0.50) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL29365209 | 0.84 | MAPT (0.50) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL21331700 | 0.84 | MAPT (0.60) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL16943506 | 0.83 | ALDH1A1 (0.53) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL11820701 | 0.83 | ALDH1A1 (0.51) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL9655337 | 0.83 | MAPT (0.53) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL16063141 | 0.83 | ALDH1A1 (0.51) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 | |
| SCHEMBL13788938 | 0.82 | MAPT (0.56) | MAPTALDH1A1HPGDSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178559-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-05-15 | — | — | US | disclosed |
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8084450-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-12-27 | — | — | US | disclosed |
| US-20110263560-A1 | Organic Compounds | NOVARTIS AG (CH) | 2011-10-27 | — | — | US | disclosed |
| US-20090312304-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-12-17 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| US-20080242662-A1 | Organic Compounds | NIHONYANAGI ATSUKO | 2008-10-02 | — | — | US | disclosed |
| WO-2006128659-A2 | PIPERAZINE DERIVATIVE RENIN INHIBITORS. | NOVARTIS AG (CH) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242662-A1 | Organic Compounds | REN, ACE, ECE1 | MAPT 1863/4885ALDH1A1 13/4885HPGD 494/4885 |
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | MAPT 1089/4885ALDH1A1 38/4885HPGD 723/4885 |
| US-20110263560-A1 | Organic Compounds | REN, ACE, OTC | MAPT 1212/4885ALDH1A1 21/4885HPGD 343/4885 |
| US-20090312304-A1 | ORGANIC COMPOUNDS | REN, ACE, PIGO | MAPT 1109/4885ALDH1A1 36/4885HPGD 225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.