Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920578 | 0.92 | PDE3B (0.49) | PDE3BPDE3ADRD2KCNH2NR3C1 | |
| Hydrochloric Acid SCHEMBL7294149 | 0.91 | PDE3B (0.48) | PDE3BPDE3ADRD2KCNH2NR3C1 | |
| Hydrochloric Acid SCHEMBL8920934 | 0.82 | CRBN (0.45) | PDE3BPDE3ADRD2KCNH2NR3C1 | |
| SCHEMBL8922923 | 0.80 | CRBN (0.48) | PDE3BPDE3AKCNH2NR3C1PGR | |
| Hydrochloric Acid SCHEMBL8919117 | 0.79 | CRBN (0.46) | PDE3BPDE3ADRD3KCNH2NR3C1 | |
| SCHEMBL8919197 | 0.79 | CRBN (0.47) | PDE3BPDE3AKCNH2NR3C1PGR | |
| SCHEMBL7286684 | 0.78 | CRBN (0.50) | PDE3BPDE3AKCNH2NR3C1PGR | |
| SCHEMBL11042441 | 0.75 | NR3C1 (0.66) | PDE3BPDE3ADRD2DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL11042650 | 0.75 | DRD3 (0.66) | PDE3BPDE3ADRD2DRD3KCNH2 | |
| SCHEMBL11044734 | 0.73 | KCNA5 (0.63) | DRD2DRD3ALDH1A1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591751-A | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0636128-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994019339-A1 | PIPERAZINOCARBONYLCARBOSTYRILS AS PERIPHERAL VASODILATORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-09-01 | — | — | WO | disclosed |