Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.35 |
| ▸ | CCKBR | P32239 | 4/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8921399 | 0.89 | TACR1 (0.35) | PLA2G10PLA2G5KDM4ELMNAMAPT | |
| SCHEMBL8920724 | 0.68 | CCKBR (0.42) | MAPTRIPK1CCKBR | |
| SCHEMBL8920740 | 0.68 | CCKBR (0.36) | RIPK1CCKBR | |
| SCHEMBL8235751 | 0.65 | GLS (0.47) | LMNASMN1; SMN2RIPK1NPSR1 | |
| SCHEMBL14664132 | 0.65 | GLS (0.47) | LMNASMN1; SMN2RIPK1NPSR1 | |
| SCHEMBL8923672 | 0.65 | CCKBR (0.66) | CCKBR | |
| SCHEMBL8922877 | 0.64 | PLG (0.39) | POLB | |
| SCHEMBL6574223 | 0.62 | MAPT (0.45) | LMNAMAPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8924334 | 0.60 | RAMP1 (0.50) | PLA2G10PLA2G5KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL17157187 | 0.60 | ABCB1 (0.43) | ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |