Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13836016 | 0.82 | TDP1 (0.52) | CYP1A2TDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL1173852 | 0.80 | TDP1 (0.54) | CYP1A2TDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL9789544 | 0.78 | CYP1A2 (0.36) | CYP1A2TDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL2289877 | 0.78 | TSHR (0.50) | TDP1HSD17B10TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL28123479 | 0.77 | TDP1 (0.47) | CYP1A2TDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL7832200 | 0.77 | GPR35 (0.50) | CYP1A2TDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL21708107 | 0.73 | ALDH1A1 (0.41) | CYP1A2TDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL8831878 | 0.73 | AR (0.43) | CYP1A2TDP1HSD17B10TSHRCYP3A4 | |
| SCHEMBL8374 | 0.72 | TDP1 (0.54) | TDP1HSD17B10TSHRCYP3A4SMN1; SMN2 | |
| SCHEMBL7821293 | 0.72 | TDP1 (0.44) | TDP1HSD17B10TSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594152-A | Process for the preparation of tricyclic-heterocycles | AMERICAN CYANAMID COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5436333-A | Process for the preparation of tricyclic-heterocycles | AMERICAN CYANAMID COMPANY (US) | 1995-07-25 | — | — | US | disclosed |