Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PTPRC | P08575 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9671719 | 0.80 | NOTUM (0.51) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL6001534 | 0.78 | MAPK14 (0.48) | ALDH1A1KDM4EHPGDLMNAMAPK1 | |
| SCHEMBL6000950 | 0.77 | STAT3 (0.46) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL5924638 | 0.76 | HPGD (0.57) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL5924685 | 0.76 | NOTUM (0.50) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL4915977 | 0.76 | CES1 (0.47) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL20187563 | 0.76 | ALDH1A1 (0.56) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL1825175 | 0.74 | MAPK14 (0.60) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL5924634 | 0.72 | L3MBTL1 (0.50) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL13924972 | 0.72 | NR1H2 (0.41) | NOTUMALDH1A1KDM4EHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-9003061-A | — | — | None | — | — | JP | disclosed |
| JP-H093061-A | INDENOTHIOPHENE COMPOUND AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR CONTAINING THE SAME | RICOH CO LTD | 1997-01-07 | — | — | JP | disclosed |
| EP-0137333-B1 | SPIRO-TRICYCLICAROMATIC SUCCINIMIDE DERIVATIVES AS INHIBITORS OF ALDOSE REDUCTASE | ALCON LABORATORIES, INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5153211-A | Enzyme inhibitors | ALCON LABORATORIES, INC. (US) | 1992-10-06 | — | — | US | disclosed |
| US-5070100-A | COMPLICATIONS OF DIABETES | ALCON LABORATORIES, INC. (US) | 1991-12-03 | — | — | US | disclosed |
| US-4864028-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| US-4537892-A | ANTIDIABETIC AGENTS | ALCON LABORATORIES, INC. (US) | 1985-08-27 | — | — | US | disclosed |