Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 10/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8920898 | 0.92 | CCKBR (0.41) | CCKBR | |
| SCHEMBL8920904 | 0.92 | CCKBR (0.41) | CCKBR | |
| SCHEMBL8920335 | 0.92 | CCKBR (0.35) | CCKBR | |
| SCHEMBL8920329 | 0.92 | CCKBR (0.35) | CCKBR | |
| SCHEMBL8922436 | 0.90 | OPRM1 (0.35) | CCKBRGRIN2BCCR2KCNH2MAPT | |
| SCHEMBL8922438 | 0.90 | OPRM1 (0.35) | CCKBRGRIN2BCCR2KCNH2MAPT | |
| SCHEMBL8920274 | 0.90 | CCKBR (0.45) | CCKBR | |
| SCHEMBL8919614 | 0.90 | CCKBR (0.38) | CCKBRLMNASMN1; SMN2HTT | |
| SCHEMBL8922339 | 0.90 | CCKBR (0.38) | CCKBRLMNASMN1; SMN2HTT | |
| SCHEMBL8921471 | 0.90 | CCKBR (0.45) | CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5643904-A | Substituted hexahdryoazepinones and tetrahydrobenzazepinones | PFIZER INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5484917-A | FOR TREATMENT AND PREVENTION OF GASTROINTESTINAL DISORDERS, PAIN AND ANXIETY | PFIZER INC. (US) | 1996-01-16 | — | — | US | disclosed |
| EP-0625145-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1994-11-23 | — | — | EP | disclosed |