Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.61 |
| ▸ | DAGLA | Q9Y4D2 | 12/20 | 0.57 |
| ▸ | ABHD6 | Q9BV23 | 8/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.55 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.53 |
| ▸ | DAGLB | Q8NCG7 | 2/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629395 | 1.00 | HSD11B1 (0.61) | HSD11B1DAGLAABHD6MEN1NPC1 | |
| Hydrochloric Acid SCHEMBL29238125 | 0.98 | HSD11B1 (0.60) | HSD11B1DAGLAABHD6MEN1NPC1 | |
| SCHEMBL23459127 | 0.95 | SCD5 (0.57) | HSD11B1DAGLAABHD6MEN1NPC1 | |
| SCHEMBL908981 | 0.95 | SCD5 (0.57) | HSD11B1DAGLAABHD6MEN1NPC1 | |
| SCHEMBL18862950 | 0.88 | HSD11B1 (0.48) | HSD11B1DAGLAABHD6SCD5GABRA1 | |
| SCHEMBL18862951 | 0.88 | HSD11B1 (0.48) | HSD11B1DAGLAABHD6SCD5GABRA1 | |
| SCHEMBL21138521 | 0.88 | HSD11B1 (0.62) | HSD11B1DAGLAABHD6MEN1NPC1 | |
| SCHEMBL27651068 | 0.88 | HSD11B1 (0.58) | HSD11B1DAGLAABHD6MEN1NPC1 | |
| SCHEMBL6429540 | 0.88 | HSD11B1 (0.58) | HSD11B1DAGLAABHD6MEN1NPC1 | |
| SCHEMBL11481440 | 0.86 | HSD11B1 (0.57) | HSD11B1DAGLAABHD6MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699032-B | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113603675-A | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2021-11-05 | — | — | CN | disclosed |
| EP-3440078-A1 | HETEROCYCLIC GPR119 AGONIST COMPOUNDS | MANKIND PHARMA LTD (IN) | 2019-02-13 | — | — | EP | disclosed |
| WO-2017175066-A1 | HETEROCYCLIC GPR119 AGONIST COMPOUNDS | MANKIND PHARMA LTD. (IN) | 2017-10-12 | — | — | WO | disclosed |
| EP-1879873-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK Holdings Co., Ltd. (KR) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006112685-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK HOLDINGS CO., LTD. (KR) | 2006-10-26 | — | — | WO | disclosed |