Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 11/20 | 0.51 |
| ▸ | ABHD6 | Q9BV23 | 8/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | DAGLB | Q8NCG7 | 3/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698218 | 0.90 | NR1H2 (0.54) | DAGLAABHD6NR1H2NR1H3HSD11B1 | |
| SCHEMBL698422 | 0.90 | NR1H2 (0.54) | DAGLAABHD6NR1H2NR1H3HSD11B1 | |
| SCHEMBL27854990 | 0.90 | NR1H2 (0.54) | DAGLAABHD6NR1H2NR1H3HSD11B1 | |
| SCHEMBL28334140 | 0.84 | NR1H2 (0.56) | DAGLANR1H2NR1H3 | |
| SCHEMBL28334137 | 0.84 | NR1H2 (0.56) | DAGLANR1H2NR1H3 | |
| SCHEMBL3812261 | 0.83 | DAGLA (0.46) | DAGLAABHD6NR1H2NR1H3HSD11B1 | |
| SCHEMBL24881522 | 0.82 | KDM1A (0.46) | DAGLAABHD6NR1H2NR1H3HSD11B1 | |
| SCHEMBL22036268 | 0.81 | HPGD (0.49) | DAGLAABHD6NR1H2NR1H3KDM1A | |
| SCHEMBL20828170 | 0.80 | PRMT5 (0.53) | DAGLAABHD6NR1H2NR1H3KDM1A | |
| SCHEMBL20828162 | 0.80 | GPR119 (0.48) | DAGLAABHD6NR1H2NR1H3KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646144-A | FOR TREATING DISORDERS IN WHICH SUBSTANCE P PLAYS A PART IN DEVELOPMENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| US-5541195-A | SUBSTANCE P ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| US-5310743-A | Substance P antagonist | CIBA-GEIGY CORP. (US) | 1994-05-10 | — | — | US | disclosed |