Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | PHGDH | O43175 | 2/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8495017 | 0.80 | MAPT (0.51) | SMN1; SMN2ALDH1A1KMT2AMAPTPHGDH | |
| SCHEMBL541208 | 0.79 | GSK3B (1.00) | GSK3BSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL10131844 | 0.78 | MGLL (0.68) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| SCHEMBL11659648 | 0.76 | SMN1; SMN2 (0.70) | GSK3BSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL14058819 | 0.75 | GSK3B (0.65) | GSK3BSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL15651912 | 0.75 | MGLL (0.44) | SMN1; SMN2ALDH1A1KMT2AMAPTLMNA | |
| SCHEMBL13185332 | 0.74 | FKBP1A (0.51) | SMN1; SMN2NPC1RAB9AALDH1A1KMT2A | |
| Bromide SCHEMBL14054592 | 0.74 | GSK3B (0.63) | GSK3BSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL16787545 | 0.73 | L3MBTL1 (0.58) | GSK3BSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL17065052 | 0.73 | L3MBTL1 (0.65) | GSK3BSMN1; SMN2NPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |