Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924222 | 0.91 | MAPT (0.47) | DRD3MAPTLMNAGFERSMO | |
| SCHEMBL8923621 | 0.76 | HTR3A (0.50) | DRD3LMNADRD4DRD2NPC1 | |
| SCHEMBL8630582 | 0.76 | MAPT (0.54) | MAPTLMNAGFERSMOPOLB | |
| SCHEMBL8921653 | 0.75 | HRH3 (0.52) | LMNADRD2NPC1ALDH1A1RAB9A | |
| SCHEMBL1388900 | 0.70 | DRD3 (0.49) | DRD3MAPTLMNAGFERSMO | |
| SCHEMBL7405310 | 0.70 | SIGMAR1 (0.70) | DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL21361433 | 0.67 | DRD2 (0.68) | MAPTLMNAGFERPOLBDRD4 | |
| Hydrochloric Acid SCHEMBL8811363 | 0.67 | DRD3 (0.53) | DRD3MAPTLMNAPOLBDRD4 | |
| Hydrochloric Acid SCHEMBL8811368 | 0.67 | DRD3 (0.53) | DRD3MAPTLMNAPOLBDRD4 | |
| SCHEMBL8019505 | 0.66 | HIF1A (0.58) | MAPTLMNASMONPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686480-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | claimed |
| US-5686480-A | Fused tricyclic heteroaromatic derivatives as dopamine receptor subtype ligands | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |