Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.45 |
| ▸ | PPARG | P37231 | 8/20 | 0.43 |
| ▸ | PPARD | Q03181 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FABP2 | P12104 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924428 | 0.92 | PPARA (0.42) | PPARAPPARGPPARDMEN1CYP1A2 | |
| SCHEMBL8768759 | 0.80 | PPARA (0.53) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL9111447 | 0.74 | PPARA (0.47) | PPARAPPARGPPARDCYP2C19MAPT | |
| SCHEMBL8924425 | 0.72 | PPARA (0.44) | PPARAPPARGPPARDCYP1A2CYP3A4 | |
| SCHEMBL8767768 | 0.72 | PPARA (0.56) | PPARAPPARGPPARD | |
| SCHEMBL8768938 | 0.71 | PPARA (0.54) | PPARAPPARGPPARD | |
| SCHEMBL8768939 | 0.71 | PPARA (0.45) | PPARAPPARGPPARDALDH1A1MEN1 | |
| SCHEMBL8767844 | 0.68 | PPARA (0.58) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL8925677 | 0.67 | PPARG (0.38) | PPARGPPARDALDH1A1EPHX2 | |
| SCHEMBL8768086 | 0.67 | PPARA (0.61) | PPARAPPARGPPARDALDH1A1FABP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0639178-B1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | WELLCOME FOUND (GB) | 1997-09-03 | — | — | EP | disclosed |