Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 7/20 | 0.55 |
| ▸ | CCKAR | P32238 | 1/20 | 0.55 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.51 |
| ▸ | GABRP | O00591 | 1/20 | 0.51 |
| ▸ | GABRD | O14764 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.51 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.51 |
| ▸ | GABRE | P78334 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045163 | 0.72 | GABRA1 (0.72) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL4701785 | 0.71 | CCKBR (0.68) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL5803563 | 0.71 | PSEN1 (0.69) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL13502675 | 0.71 | PSEN1 (0.62) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL14497508 | 0.71 | OPRK1 (0.72) | CCKBRCCKARGABRPGABRDGABRA1 | |
| SCHEMBL7207460 | 0.71 | CCKBR (0.78) | CCKBRCCKAR | |
| SCHEMBL2927644 | 0.71 | CCKBR (0.78) | CCKBRCCKAR | |
| SCHEMBL8610163 | 0.71 | CCKBR (1.00) | CCKBRCCKARKCNH2 | |
| SCHEMBL7592676 | 0.71 | CCKBR (1.00) | CCKBRCCKARKCNH2 | |
| SCHEMBL9866322 | 0.71 | CCKBR (1.00) | CCKBRCCKARKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5595990-A | TREATMENT OF CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5426185-A | Antiarrhythmia agents having reduced side effects | MERCK & CO., INC. (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995014471-A1 | ANTIARRHYTHMIC BENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |