Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428481 | 0.77 | TSHR (0.46) | HTR3AHTR7ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL9429028 | 0.77 | HTR7 (0.47) | HTR3AHTR7ALDH1A1KMT2AGALR3 | |
| SCHEMBL15565198 | 0.77 | HTR7 (0.40) | HTR3AHTR7ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL17176324 | 0.77 | ALDH1A1 (0.63) | HTR3AHTR7ALDH1A1KMT2AGALR3 | |
| SCHEMBL19643369 | 0.76 | NOTUM (0.53) | ALDH1A1NOTUMPOLBAPEX1TDP1 | |
| SCHEMBL9445884 | 0.75 | NOTUM (0.44) | HTR3AHTR7KMT2ANOTUMTSHR | |
| SCHEMBL9343076 | 0.74 | XIAP (0.44) | HTR3AHTR7ALDH1A1KMT2AGALR3 | |
| SCHEMBL17170720 | 0.74 | TSHR (0.67) | HTR3AHTR7ALDH1A1KMT2AGALR3 | |
| SCHEMBL9429365 | 0.73 | FABP4 (0.56) | ALDH1A1KMT2ANOTUMTSHRPOLB | |
| SCHEMBL2581642 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KMT2ANOTUMRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616591-A | Indole- and benzimidazole-substituted quinoline derivatives | E.R. SQUIBB & SONS, INC. (US) | 1997-04-01 | — | — | US | disclosed |
| US-5374615-A | Treating hypertension and congestive heart failure, preventing cardiac hypertrophy | E. R. SQUIBB & SONS, INC. (US) | 1994-12-20 | — | — | US | disclosed |
| US-5236916-A | Oxadiazinone substituted indole and benzimidazole derivatives | E. R. SQUIBB & SONS, INC. (US) | 1993-08-17 | — | — | US | disclosed |
| US-5208235-A | Phosphonic or phosphinic acid derivatives as inhibitors of angiotnesin II for cardiovascular disorders and hypotensives | E. R. SQUIBB & SONS, INC. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0488532-A1 | Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives | E.R. Squibb & Sons, Inc. (US) | 1992-06-03 | — | — | EP | disclosed |