Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9378909 | 0.82 | ADRA2A (0.41) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL8927561 | 0.81 | ADRA2A (0.54) | ALDH1A1KDM4ETP53SMN1; SMN2POLB | |
| SCHEMBL8927560 | 0.81 | ADRA2A (0.43) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8927261 | 0.81 | ADRA2A (0.53) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL10473943 | 0.77 | LMNA (0.39) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL9382500 | 0.77 | ADRA2A (0.59) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL9380249 | 0.76 | ALDH1A1 (0.43) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL9382761 | 0.76 | KDM4E (0.43) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL9384131 | 0.75 | ERN1 (0.39) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 | |
| SCHEMBL9378346 | 0.75 | ADRA2A (0.40) | ALDH1A1KDM4ETSHRTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5599810-A | ADMINISTERING IN TREATMENT OF BENIGN PROSTATIC HYPERTROPHY, PERIPHERAL VASCULAR DISEASE AND CONGESTIVE HEART FAILURE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-02-04 | — | — | US | disclosed |
| EP-0684949-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0684949-A4 | CHEMICAL COMPOUNDS. | SMITHKLINE BEECHAM CORP (US) | 1995-10-13 | — | — | EP | disclosed |
| WO-1994019354-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-09-01 | — | — | WO | disclosed |