SCHEMBL8926426

SCHEMBL8926426

CCOC(=O)NC1C=CC(C)CC1C(=O)OC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 1/20 0.40
NFKB2 Q00653 1/20 0.40
RELA Q04206 1/20 0.40
CPB1 P15086 1/20 0.36
MAPT P10636 1/20 0.35
CYP2C19 P33261 3/20 0.34
ALDH1A1 P00352 2/20 0.34
CYP1A2 P05177 2/20 0.34
CYP3A4 P08684 2/20 0.34
TRPM8 Q7Z2W7 1/20 0.34
CYP2C9 P11712 2/20 0.33
POLB P06746 1/20 0.33
CYP2D6 P10635 1/20 0.33
TSHR P16473 1/20 0.33
LMNA P02545 2/20 0.33
GAA P10253 1/20 0.32
GLA P06280 1/20 0.31
KDM4E B2RXH2 1/20 0.31
CA1 P00915 3/20 0.30
CA2 P00918 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8926330 0.83 CYP1A2 (0.36) MAPTCYP2C19ALDH1A1CYP1A2CYP3A4
SCHEMBL14651067 0.81 CPB1 (0.60) CPB1CYP2C19ALDH1A1CYP1A2CYP3A4
SCHEMBL9325381 0.78 NFKB1 (0.39) NFKB1NFKB2RELACYP2C19ALDH1A1
SCHEMBL8924066 0.77 MAPT (0.58) NFKB1NFKB2RELACPB1MAPT
SCHEMBL8926505 0.71 NFKB1 (0.40) NFKB1NFKB2RELAMAPTCYP2C19
SCHEMBL11158247 0.70 ALDH1A1 (0.43) NFKB1NFKB2RELACPB1CYP2C19
SCHEMBL8461792 0.69 CA1 (0.37) MAPTALDH1A1GAAKDM4ECA1
SCHEMBL4354339 0.69 CPB1 (0.40) NFKB1NFKB2RELACPB1TRPM8
SCHEMBL4354337 0.69 CPB1 (0.40) NFKB1NFKB2RELACPB1TRPM8
SCHEMBL24318092 0.69 CA1 (0.44) GAACA1CA2CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0376072-B1 Fungicidal and herbicidal agents and substituted 2-cyclohexen-1-yl amine derivatives, and their preparation BAYER AG (DE) 1994-02-16 EP claimed
US-5622916-A PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-04-22 US disclosed
US-5296503-A Administering orally BAYER AKTIENGESELLSCHAFT (DE) 1994-03-22 US disclosed
US-5270340-A Substituted 2-cyclohexen-1-yl-amine fungicidal and herbicidal agents BAYER AKTIENGESELLSCHAFT (DE) 1993-12-14 US disclosed