Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8925596 | 0.90 | EPHX2 (0.34) | L3MBTL1KDM4EALDH1A1PSEN1PSEN2 | |
| SCHEMBL7622297 | 0.73 | PPARA (0.37) | KDM4EMAOBALDH1A1PSEN1PSEN2 | |
| SCHEMBL8483788 | 0.72 | PSMB5 (0.37) | KDM4EALDH1A1PSMB5LMNAMAPT | |
| SCHEMBL8926136 | 0.70 | TACR1 (0.47) | TACR1SMN1; SMN2TSHRSLC6A2SLC6A4 | |
| SCHEMBL6005075 | 0.63 | KMO (0.48) | SLC6A2SLC6A4SLC6A3PNMTPSMB5 | |
| SCHEMBL6005266 | 0.63 | KMO (0.48) | SLC6A2SLC6A4SLC6A3PNMTPSMB5 | |
| SCHEMBL7492398 | 0.63 | SLC6A3 (0.48) | SMN1; SMN2TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8582269 | 0.62 | PNMT (0.47) | TACR1TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8581618 | 0.62 | PNMT (0.47) | TACR1TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2163757 | 0.62 | SMN1; SMN2 (0.56) | TACR1SMN1; SMN2TSHRL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646144-A | FOR TREATING DISORDERS IN WHICH SUBSTANCE P PLAYS A PART IN DEVELOPMENT | CIBA-GEIGY CORPORATION (US) | 1997-07-08 | — | — | US | disclosed |
| EP-0532456-B1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA GEIGY AG (CH) | 1995-03-29 | — | — | EP | disclosed |
| US-5310743-A | Substance P antagonist | CIBA-GEIGY CORP. (US) | 1994-05-10 | — | — | US | disclosed |
| EP-0532456-A1 | 1-Acylpiperidine derivatives and their use as substance P antagonists | CIBA-GEIGY AG (CH) | 1993-03-17 | — | — | EP | disclosed |