Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | FABP2 | P12104 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14345534 | 0.83 | MEN1 (0.58) | KMT2AMEN1MAPTGAAALDH1A1 | |
| SCHEMBL8768887 | 0.83 | KDM4E (0.55) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL2409902 | 0.81 | KMT2A (0.63) | KMT2AMEN1MAPTGAAHPGD | |
| SCHEMBL14345282 | 0.79 | KMT2A (0.48) | KMT2AMEN1MAPTGAAHPGD | |
| SCHEMBL8925777 | 0.78 | PPARA (0.62) | KMT2AMEN1MAPTGAAALDH1A1 | |
| SCHEMBL8768931 | 0.78 | PPARA (0.52) | MAPTGAAALDH1A1HTTPPARA | |
| SCHEMBL9233473 | 0.77 | KMT2A (0.60) | KMT2AMEN1MAPTGAAALDH1A1 | |
| SCHEMBL11571602 | 0.77 | KDM4E (0.59) | MAPTALDH1A1PPARAFABP2PPARG | |
| SCHEMBL8926283 | 0.77 | PPARA (0.68) | KMT2AMEN1MAPTPPARAPPARG | |
| SCHEMBL8768942 | 0.77 | KMT2A (0.57) | KMT2AMEN1MAPTGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658944-A | ANTICHOLESTEROL AGENTS | THE UNIVERSITY OF SOUTH CAROLINA (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0639178-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS. | WELLCOME FOUND (GB) | 1995-02-22 | — | — | EP | disclosed |
| WO-1992010468-A1 | ANTI-ATHEROSCLEROTIC ARYL COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-06-25 | — | — | WO | disclosed |