SCHEMBL8926651

SCHEMBL8926651

CCCCNC(=O)C(Cl)CCl

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A2 O94788 1/20 0.47
ALDH1A1 P00352 1/20 0.47
ALDH2 P05091 1/20 0.47
ALDH1A3 P47895 1/20 0.47
DPP7 Q9UHL4 2/20 0.46
EPHX1 P07099 4/20 0.45
FNTA P49354 1/20 0.44
FNTB P49356 1/20 0.44
ACHE P22303 7/20 0.42
MMP2 P08253 1/20 0.42
RRM1 P23921 1/20 0.42
FAAH O00519 1/20 0.42
GNAI3 P08754 1/20 0.40
GNAO1 P09471 1/20 0.40
GNAI1 P63096 1/20 0.40
MMP8 P22894 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10400683 0.92 EPHX1 (0.53) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL10399529 0.92 EPHX1 (0.53) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL6461481 0.88 USP2 (0.41) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL28077769 0.80 DPP7 (0.55) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL10582035 0.79 ALDH1A1 (0.42) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL9351242 0.79 ALDH1A2 (0.50) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL7404199 0.79 ALDH1A2 (0.50) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL8924516 0.79
SCHEMBL5001334 0.78 ACHE (0.46) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7
SCHEMBL10579232 0.77 GNAI3 (0.57) ALDH1A2ALDH1A1ALDH2ALDH1A3DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2938641-A1 MOLECULARLY IMPRINTED POLYMERS AND THEIR USE AS ANTIDANDRUFF AGENTS L'Oréal (FR) 2015-11-04 EP disclosed
WO-2014102206-A1 MOLECULARLY IMPRINTED POLYMERS AND THEIR USE AS ANTIDANDRUFF AGENTS L'OREAL (FR) 2014-07-03 WO disclosed
US-5663365-A Process for the preparation of pyrazolones JAPAN HYDRAZINE CO., LTD. (JP) 1997-09-02 US disclosed