Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9456969 | 0.90 | POLB (0.52) | POLBKMT2ABCHECHRNEMEN1 | |
| SCHEMBL8811666 | 0.90 | KMT2A (0.54) | POLBKMT2ABCHECHRNEMEN1 | |
| SCHEMBL9457409 | 0.83 | KMT2A (0.66) | POLBKMT2ABCHECHRNEMEN1 | |
| SCHEMBL8927401 | 0.83 | POLB (0.45) | POLBKMT2ABCHECHRNELMNA | |
| SCHEMBL10277001 | 0.79 | MEN1 (0.47) | POLBKMT2AMEN1LMNADEGS1 | |
| SCHEMBL8810087 | 0.75 | KMT2A (0.39) | POLBKMT2ABCHECHRNEMEN1 | |
| SCHEMBL9457262 | 0.72 | POLB (0.50) | POLBKMT2ABCHECHRNELMNA | |
| SCHEMBL11070469 | 0.72 | BRD9 (0.54) | POLBKMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL8927579 | 0.72 | KMT2A (0.40) | POLBKMT2ABCHECHRNEMEN1 | |
| Water SCHEMBL9457015 | 0.71 | POLB (0.49) | POLBKMT2ABCHECHRNELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607932-A | Heterocyclic derivatives of azolones | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-04 | — | — | US | disclosed |