Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | SOD1 | P00441 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.50 |
| ▸ | CHRNE | Q04844 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8811666 | 0.91 | KMT2A (0.54) | KMT2AMEN1SOD1L3MBTL1BCHE | |
| SCHEMBL9456969 | 0.89 | POLB (0.52) | KMT2AMEN1SOD1BCHECHRNE | |
| SCHEMBL8927049 | 0.83 | POLB (0.47) | KMT2AMEN1BCHECHRNEPOLB | |
| SCHEMBL11075143 | 0.81 | L3MBTL1 (0.65) | KMT2AMEN1L3MBTL1BCHECHRNE | |
| SCHEMBL11072138 | 0.78 | L3MBTL1 (0.61) | KMT2AMEN1L3MBTL1BCHECHRNE | |
| SCHEMBL10277001 | 0.78 | MEN1 (0.47) | KMT2AMEN1SOD1POLBRAB9A | |
| SCHEMBL8927579 | 0.76 | KMT2A (0.40) | KMT2AMEN1SOD1L3MBTL1BCHE | |
| SCHEMBL11073079 | 0.75 | BRD9 (0.56) | KMT2AL3MBTL1RAB9AMAPTALDH1A1 | |
| SCHEMBL9457262 | 0.72 | POLB (0.50) | KMT2AL3MBTL1BCHECHRNEPOLB | |
| SCHEMBL8810087 | 0.72 | KMT2A (0.39) | KMT2AMEN1L3MBTL1BCHECHRNE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254553-A | 4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-19 | — | — | US | disclosed |
| EP-0532091-A1 | 4-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)-phenyl)-5-methyl-3H-1,2,4-triazol-3-one derivatives as 5-lipoxygenase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-17 | — | — | EP | disclosed |