Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ME2 | P23368 | 1/20 | 0.45 |
| ▸ | ME1 | P48163 | 1/20 | 0.45 |
| ▸ | ME3 | Q16798 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SOD1 | P00441 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8927049 | 0.90 | POLB (0.47) | POLBKMT2ABCHECHRNEMEN1 | |
| SCHEMBL9457409 | 0.89 | KMT2A (0.66) | POLBKMT2ABCHECHRNEMEN1 | |
| SCHEMBL10277001 | 0.89 | MEN1 (0.47) | POLBKMT2AMEN1TP53RAB9A | |
| SCHEMBL8811666 | 0.83 | KMT2A (0.54) | POLBKMT2ABCHECHRNEMEN1 | |
| SCHEMBL11070469 | 0.81 | BRD9 (0.54) | POLBKMT2AMEN1LMNACYP2C19 | |
| SCHEMBL9457262 | 0.81 | POLB (0.50) | POLBKMT2ABCHECHRNETP53 | |
| Water SCHEMBL9457015 | 0.80 | POLB (0.49) | POLBKMT2ABCHECHRNETP53 | |
| SCHEMBL11069372 | 0.78 | MAPT (0.49) | POLBKMT2ARAB9ALMNACYP2C19 | |
| SCHEMBL9462045 | 0.77 | MAPT (0.45) | POLBKMT2AMEN1TP53LMNA | |
| SCHEMBL8810087 | 0.76 | KMT2A (0.39) | POLBKMT2ABCHECHRNEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254553-A | 4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-19 | — | — | US | claimed |
| EP-0532091-A1 | 4-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)-phenyl)-5-methyl-3H-1,2,4-triazol-3-one derivatives as 5-lipoxygenase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-17 | — | — | EP | claimed |
| JP-5194436-A | — | — | None | — | — | JP | disclosed |
| EP-0571416-A1 | (CARBOXYL)ALKYLOXYALKYL DERIVATIVES OF CYCLODEXTRINS | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-01 | — | — | EP | disclosed |
| US-5254553-A | 4-[4- [4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-5-methyl-3H-1,2,4-triazol-3-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-19 | — | — | US | disclosed |
| JP-H05194436-A | 4-(4-(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL)-5-METHYL-3 H-1,2-4-TRIAZOL-3-ONE DERIVATIVES | JANSSEN PHARMACEUT NV | 1993-08-03 | — | — | JP | disclosed |
| EP-0532091-A1 | 4-(4-(4-(4-hydroxyphenyl)-1-piperazinyl)-phenyl)-5-methyl-3H-1,2,4-triazol-3-one derivatives as 5-lipoxygenase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-17 | — | — | EP | disclosed |
| WO-1992014762-A1 | (CARBOXYL)ALKYLOXYALKYL DERIVATIVES OF CYCLODEXTRINS | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-03 | — | — | WO | disclosed |
| EP-0499322-A1 | (Carboxyl)alkyloxyalkyl derivatives of cyclodextrins | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-08-19 | — | — | EP | disclosed |