SCHEMBL8928249

SCHEMBL8928249

C=C(NC(=O)OCC)C(=O)OCC

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.45
TSHR P16473 1/20 0.45
MGAM O43451 1/20 0.41
GAA P10253 1/20 0.41
SI P14410 1/20 0.41
MGAM2 Q2M2H8 1/20 0.41
EGLN1 Q9GZT9 1/20 0.39
MAPT P10636 2/20 0.38
NPSR1 Q6W5P4 1/20 0.38
GLO1 Q04760 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TRPM8 Q7Z2W7 1/20 0.37
CYP2D6 P10635 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
LMNA P02545 1/20 0.37
HSD17B10 Q99714 1/20 0.37
ALOX15 P16050 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10659111 0.89 ALDH1A1 (0.44) ALDH1A1TSHRMGAMGAASI
SCHEMBL4650635 0.89 ALDH1A1 (0.39) ALDH1A1TSHRMGAMGAASI
SCHEMBL27676157 0.88 THRB (0.39) ALDH1A1TSHRMGAMGAASI
SCHEMBL9067345 0.87 ACHE (0.40) ALDH1A1TSHRMGAMGAASI
SCHEMBL23748637 0.86 ALDH1A1 (0.37) ALDH1A1TSHRMGAMGAASI
SCHEMBL28204473 0.86 ALDH1A1 (0.37) ALDH1A1TSHRMGAMGAASI
SCHEMBL28157463 0.85 TSHR (0.47) ALDH1A1TSHRMAPTNPSR1L3MBTL1
SCHEMBL23301669 0.84 ALDH1A1 (0.36) ALDH1A1TSHRMGAMGAASI
SCHEMBL28236956 0.84 TSHR (0.39) ALDH1A1TSHRMGAMGAASI
SCHEMBL16459619 0.83 TRPM8 (0.36) ALDH1A1TSHRMGAMGAASI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1989003864-A1 ALPHA-SUBSTITUTED ACRYLIC ACID ESTERS, THEIR POLYMERS AND METHOD OF SYNTHESIZING SAME MIDWEST RESEARCH INSTITUTE (US) 1989-05-05 WO claimed
EP-0495269-B1 Thermosetting reactive resin mixture, moulded article and coating made therefrom DAINIPPON INK & CHEMICALS (JP) 1997-03-05 EP disclosed
EP-0189945-B2 Aqueous polyurethane-polyolefin compositions WITCO CORP (US) 1994-11-30 EP disclosed
US-5292833-A Polyepoxide compound, carbamate compound and catalyst DAINIPPON INK AND CHEMICALS, INC. (JP) 1994-03-08 US disclosed
WO-1992012192-A2 THERMOSETTING REACTIVE RESIN MIXTURE, MOULDED ARTICLE AND COATING MADE THEREFROM DAINIPPON INK & CHEMICALS, INC. (JP) 1992-07-23 WO disclosed
EP-0495269-A2 Thermosetting reactive resin mixture, moulded article and coating made therefrom DAINIPPON INK AND CHEMICALS, INC. (JP) 1992-07-22 EP disclosed
EP-0189945-B1 AQUEOUS POLYURETHANE-POLYOLEFIN COMPOSITIONS WITCO CORPORATION (US) 1990-01-10 EP disclosed
US-4876323-A α-substituted acrylic acid esters, their polymers and method of synthesizing same MIDWEST RESEARCH INSTITUTE (US) 1989-10-24 US disclosed
WO-1989003864-A1 ALPHA-SUBSTITUTED ACRYLIC ACID ESTERS, THEIR POLYMERS AND METHOD OF SYNTHESIZING SAME MIDWEST RESEARCH INSTITUTE (US) 1989-05-05 WO disclosed
US-4704466-A α-substituted acrylic acid esters MIDWEST RESEARCH INSTITUTE (US) 1987-11-03 US disclosed
US-4644030-A FORMING POLYURETHANE PREPOLYMER IN INERT POLYMERIZABLE ETHYLENTICALLY UNSATURATED MONOMER, DISPERSING IN WATER, CHAIN EXTENDING, AND POLYMERIZING WITCO CORPORATION (US) 1987-02-17 US disclosed
EP-0189945-A2 Aqueous polyurethane-polyolefin compositions WITCO CORPORATION (US) 1986-08-06 EP disclosed
EP-0098357-B1 MODIFIED RESISTIVE LAYER IN THERMAL TRANSFER MEDIUM International Business Machines Corporation (US) 1985-11-27 EP disclosed
EP-0098357-A1 Modified resistive layer in thermal transfer medium International Business Machines Corporation (US) 1984-01-18 EP disclosed