Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.62 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.62 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8928075 | 0.98 | MTNR1A (0.62) | MTNR1AMTNR1BNQO2KMT2AALDH1A1 | |
| SCHEMBL8928078 | 0.95 | MTNR1A (0.65) | MTNR1AMTNR1BKMT2AHDAC1HDAC6 | |
| SCHEMBL8928226 | 0.91 | MTNR1A (0.70) | MTNR1AMTNR1BALDH1A1PKM | |
| SCHEMBL5530350 | 0.83 | ALDH1A1 (0.72) | KMT2AALDH1A1POLBPKMCYP3A4 | |
| SCHEMBL8928132 | 0.81 | MTNR1A (0.92) | MTNR1AMTNR1BKMT2AHDAC1HDAC6 | |
| SCHEMBL8928103 | 0.79 | MTNR1A (0.69) | MTNR1AMTNR1BKMT2AHDAC1HDAC6 | |
| SCHEMBL8928088 | 0.79 | MTNR1A (0.92) | MTNR1AMTNR1BHDAC1HDAC6 | |
| SCHEMBL31036087 | 0.78 | MTNR1A (0.90) | MTNR1AMTNR1BHDAC1HDAC6 | |
| SCHEMBL8928131 | 0.78 | MTNR1A (0.68) | MTNR1AMTNR1BKMT2AHDAC1HDAC6 | |
| SCHEMBL8928133 | 0.78 | MTNR1A (0.67) | MTNR1AMTNR1BNQO2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541228-A | Melatonergic agents | BRISTOL-MYERS SQUIBB CO. (US) | 1996-07-30 | — | — | US | claimed |
| EP-0706994-A1 | Melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-17 | — | — | EP | claimed |
| US-5661185-A | AN ALKOXYPHENYL-ALKYLUREA COMPOUND TREATING SLEEP DISORDER | BRISTOL-MYERS SQUIBB CO. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5541228-A | Melatonergic agents | BRISTOL-MYERS SQUIBB CO. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0706994-A1 | Melatonergic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-04-17 | — | — | EP | disclosed |