Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 4/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.40 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8929582 | 0.85 | CDC7 (0.57) | CDC7DBF4JAK2CSF1RJAK3 | |
| SCHEMBL24345975 | 0.75 | AKT2 (0.50) | CDC7DBF4JAK2AKT2GSK3B | |
| SCHEMBL22346237 | 0.75 | HDAC6 (0.62) | JAK2JAK1TTBK1TTBK2 | |
| SCHEMBL8929550 | 0.75 | CYP17A1 (0.42) | CDC7DBF4JAK2AKT2GSK3B | |
| SCHEMBL4006768 | 0.74 | TTBK1 (0.48) | CDC7DBF4JAK2AKT2GSK3B | |
| SCHEMBL14355258 | 0.74 | JAK2 (0.47) | CDC7DBF4JAK2AKT2GSK3B | |
| Hydrochloric Acid SCHEMBL4974811 | 0.74 | AKT2 (0.49) | CDC7DBF4JAK2AKT2GSK3B | |
| SCHEMBL8930212 | 0.74 | DAO (0.42) | CDC7DBF4AKT2NUDT1AXL | |
| SCHEMBL8928889 | 0.73 | JAK3 (0.42) | CDC7DBF4JAK2AKT2GSK3B | |
| SCHEMBL20220690 | 0.71 | TTBK1 (0.49) | CDC7DBF4JAK2AKT2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |