Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 2/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | TTBK1 | Q5TCY1 | 2/20 | 0.37 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | BMX | P51813 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834633 | 0.79 | MPO (0.42) | MPOPDE5A | |
| SCHEMBL8930219 | 0.77 | SMYD3 (0.41) | — | |
| SCHEMBL8929550 | 0.76 | CYP17A1 (0.42) | JAK2AKT2GSK3BTTBK1TTBK2 | |
| SCHEMBL8929582 | 0.74 | CDC7 (0.57) | JAK3JAK2JAK1TTBK1TTBK2 | |
| SCHEMBL20752219 | 0.74 | JAK2 (0.58) | JAK3JAK2JAK1AXLGSK3B | |
| SCHEMBL7821656 | 0.74 | MPO (0.37) | MPOPDE5A | |
| SCHEMBL7834634 | 0.74 | AKT2 (0.40) | MPOAKT2CDC7DBF4 | |
| SCHEMBL8929547 | 0.73 | CDC7 (0.42) | JAK3JAK2JAK1AXLAKT2 | |
| SCHEMBL8929209 | 0.72 | EGFR (0.63) | TTBK1TTBK2 | |
| SCHEMBL8930212 | 0.72 | DAO (0.42) | AXLAKT2CDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |