Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8929550 | 0.79 | CYP17A1 (0.42) | KDRAKT2EGFRCDC7DBF4 | |
| SCHEMBL8929582 | 0.75 | CDC7 (0.57) | METRETKDREGFRCDC7 | |
| SCHEMBL8929547 | 0.74 | CDC7 (0.42) | AKT2AXLNUDT1CDC7DBF4 | |
| SCHEMBL8928889 | 0.72 | JAK3 (0.42) | AKT2AXLCDC7DBF4 | |
| SCHEMBL10440683 | 0.72 | DAO (0.51) | DAONPC1METPDE10AKDM4E | |
| SCHEMBL27824234 | 0.69 | MET (0.53) | NPC1METPDE10AKDM4EALDH1A1 | |
| SCHEMBL30586439 | 0.68 | ALDH1A1 (0.58) | DAONPC1METKDM4EALDH1A1 | |
| SCHEMBL507149 | 0.68 | ALDH1A1 (0.58) | DAONPC1METKDM4EALDH1A1 | |
| SCHEMBL29673226 | 0.68 | ALDH1A1 (0.58) | DAONPC1METKDM4EALDH1A1 | |
| SCHEMBL28335245 | 0.68 | MET (0.47) | NPC1METPDE10AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | claimed |
| EP-0795556-A1 | 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-09-17 | — | — | EP | disclosed |