Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719081 | 0.98 | MAPT (0.56) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| Hydrochloric Acid SCHEMBL9634629 | 0.96 | MAPT (0.54) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| Pyrene SCHEMBL28845423 | 0.89 | MAPT (0.49) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| SCHEMBL1306077 | 0.82 | MAPT (0.49) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| Nitrobenzene SCHEMBL28043005 | 0.81 | MMP13 (0.56) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| SCHEMBL6001350 | 0.79 | MAPT (0.50) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| SCHEMBL288476 | 0.79 | MAPT (0.57) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| SCHEMBL221982 | 0.78 | PSMB8 (0.53) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| SCHEMBL19844258 | 0.78 | RAB9A (0.51) | MAPTRAB9ANPC1L3MBTL1CASP3 | |
| SCHEMBL29954323 | 0.78 | PSMB8 (0.53) | MAPTRAB9ANPC1L3MBTL1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997026919-A2 | METHOD OF IMAGING AMYLOID DEPOSITS | WARNER-LAMBERT COMPANY (US) | 1997-07-31 | — | — | WO | disclosed |