Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542698 | 1.00 | PTGS2 (0.44) | PTGS2CYP1A2POLBCYP3A4CYP2C9 | |
| SCHEMBL8722371 | 0.87 | PTGS2 (0.42) | PTGS2 | |
| SCHEMBL8548867 | 0.87 | PTGS2 (0.42) | PTGS2 | |
| SCHEMBL8548618 | 0.82 | GRIN2D (0.48) | CYP1A2CYP3A4 | |
| SCHEMBL8547103 | 0.82 | GRIN2D (0.48) | CYP1A2CYP3A4 | |
| SCHEMBL8930130 | 0.79 | GPR17 (0.53) | CYP3A4TSHR | |
| SCHEMBL8546223 | 0.79 | GPR17 (0.53) | CYP3A4TSHR | |
| SCHEMBL8930149 | 0.76 | MMP1 (0.45) | CYP2C9 | |
| SCHEMBL8548936 | 0.76 | MMP1 (0.45) | CYP2C9 | |
| SCHEMBL8547075 | 0.76 | ALOX15 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656626-A | NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE | ZENECA LIMITED (GB) | 1997-08-12 | — | — | US | claimed |
| EP-0702673-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1996-03-27 | — | — | EP | claimed |
| WO-1994029275-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | claimed |
| US-5656626-A | NERVOUS SYSTEM OR BRAIN DISORDERS; BENZ(B)AZEPINE | ZENECA LIMITED (GB) | 1997-08-12 | — | — | US | disclosed |
| EP-0702673-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1996-03-27 | — | — | EP | disclosed |
| WO-1994029275-A1 | BENZ(B)AZEPINE-2,5-DIONES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS | ZENECA LIMITED (GB) | 1994-12-22 | — | — | WO | disclosed |